|Linus Pauling molecular biology
Sufferers of sickle-cell disease, Linus Pauling found, have different haemoglobin molecules. This haemoglobin forms strands that deform red-blood cells, decreasing their elasticity, restricting the flow of blood, carry oxygen less efficiently and are destroyed sooner, resulting in severe anaemia, blocking small blood vessels, restricting oxygen to the organs, destroys the spleen, increases the risk of infection, and damages the kidneys and liver.
In the evil balance of nature sickle-cell disease persists as the abnormality gives resistance when inherited from only one parent to the malarial parasite.
Real crippling pain not psychological. We can replenish the blood or treat the symptoms or for children do bone-marrow transplants. Cruel and arbitrary yet impossible to refute.